蓝贤江

  • 职    称:青年研究员

  • 电    话:021-54237874

  • 电子邮箱:xianjiang_lan@fudan.edu.cn

  • 办公地点:上海市徐汇区东安路131号科研二号楼CB2-020

  • 个人主页: /sysbiom/f5/e9/c32668a390633/page.htm

  • 教育经历

  • 工作经历

  • 获得人才项目

  • 获得奖项

  • 研究方向

  • 科研项目

  • 代表性论著

  • 2011.09—2016.07  美国德克萨斯大学休斯敦健康科学中心&MD安德森癌症中心 表观遗传学和分子肿瘤发生 博士

  • 2008.09—2011.07  中山大学 遗传学 硕士

  • 2004.09—2008.07  中南民族大学 生物技术 本科

  • 2021.08—至今     williamhill官网青年研究员

  • 2016.10—2021.08  美国费城儿童医院博士后

  • 2022,临港实验室“求索杰出青年计划”,国家重点实验室

  • 2021,上海市海外高层次人才计划,上海市委组织部

  • 2020,杰出摘要成就奖,美国血液学年会

  • 2018,优秀摘要成就奖,美国血液学年会

  • 结合高通量CRISPR文库筛选技术,生物化学,多组学,高通量测序,生物信息学等全面解析血红蛋白基因表达调控机制,鉴定具有治疗地中海贫血症潜能的新靶点,合作开发和测试具有治疗地中海贫血症潜能的小分子抑制剂。

  • 解析极端特异转录因子ZNF410在发育和疾病中的功能。

  • 推广高通量分类CRISPR文库筛选技术在肝癌耐药等疾病模型中的应用,寻找新靶点。

  • 2022,国家临港实验室开放课题,“搜寻重新激活胎儿血红蛋白治疗地中海贫血症的新靶点”,主持

  • 2021,复旦大学人才引进启动资金

  • 2019,美国Cooley家族贫血症研究基金,“鉴定SPOP用于抑制胎儿血红蛋白表达的底物”,主持

  1. Lan, X., Ren, R., Feng, R., Ly, L.C., Lan, Y., Zhang, Z., Aboreden, N., Qin, K., Horton, J.R., Grevet, J.D., et al. (2021). ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol Cell 81, 239-254 e238. (Previewed)

  2. Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA. HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Adv. 2020 Sep 22;4(18):4560-4572.

  3. Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA. The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. Blood. 2020 Jun 11;135(24):2121-2132.

  4. Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Adv. 2019 May 28;3(10):1586-1597.

  5. Grevet JD*, Lan X* Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018 Jul 20;361(6399):285-290. (* equal contribution)

  6. Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYR. USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B. Cell Rep. 2016 Nov 22;17(9):2382-2393.

  7. Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY. Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Mol Cell Biol. 2016 Nov 15;36(22):2855-2866.

  8. Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY. ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. Mol Cell. 2016 May 19;62(4):558-71.

  9. Lan X*, Koutelou E*, Schibler AC, Chen YC, Grant PA, Dent SY. Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module. Mol Cell Biol. 2015 May;35(10):1777-87. (* equal contribution)